Human adipose tissue-derived mesenchymal stem cells ameliorate experimental autoimmune myasthenia gravis by modifying the balance of Th1/Th2/Th17/Treg cell subsets
نویسندگان
چکیده
Myasthenia gravis (MG) is a T cell-mediated autoimmune disease characterized by acetylcholine receptor antibodies (AChR-Ab) selectively affecting AChR of the postsynaptic membrane. Mesenchymal stem cells (MSCs) have immunosuppressive qualities including suppressing effector T cell responses and have beneficial effects in various immune disorders. The aim of this study was to evaluate the therapeutic effects of human adipose tissuederived mesenchymal stem cells (hASCs) in the model of MG. In this study, we demonstrated that intravenous injection of hASCs could ameliorate the pathological features of experimental autoimmune myasthenia gravis (EAMG). This effect was specifically dependent on the correction of imbalance among the Th1, Th2, Th17, and Treg cell subsets, which was involved in the development of EAMG. Our results suggested that hASCs emerge as potent regulators of immune/inflammatory responses with the capacity to suppress effector T cells in vivo and as attractive candidates for cell-based treatments for MG.
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